pancreatic cancer — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5S0777	Phellodendrine chloride		Others
	Phellodendrine chloride has anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli.		Others
T60028	MM41		DNA/RNA Synthesis
	MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.		DNA/RNA Synthesis
T8439	Clobenpropit dihydrobromide		Apoptosis , Histamine Receptor
	Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07)		Apoptosis , Histamine Receptor
T9050	AG-270		Others , Methionine Adenosyltransferase (MAT)
	AG-270 is an allosteric and orally active inhibitor of MAT2A.		Others , Methionine Adenosyltransferase (MAT)
T21773	SP-141	SP 141	Mdm2
	SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.		Mdm2
TN2269	Tetramethylcurcumin		Apoptosis , STAT
	Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also inhibits colony formation in soft agar, cell invasion, and e...		Apoptosis , STAT
T9593	Senaparib	IMP4297	PARP
	Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity.		PARP
T6795	Carbidopa	(S)-(-)-Carbidopa,Lodosyn	Decarboxylase , Aryl Hydrocarbon Receptor
	Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA.		Decarboxylase , Aryl Hydrocarbon Receptor
T14779	BRD7389		SGK , FLT , Pim , CDK , S6 Kinase , DAPK
	BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.		SGK , FLT , Pim , CDK , S6 Kinase , DAPK
T4964	Steviolbioside	CCRIS-6025	Others
	Steviolbioside (CCRIS-6025) is a natural sweetener, it presents notable inhibition on human hepatocarcinoma cell Hep3B, human breast cancer cell MDA-MB-231 and human pancreatic cancer cell BxPC-3, thus, steviolbioside(CC...		Others
T8901	YUM70		Apoptosis , GPR , HSP
	YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediate...		Apoptosis , GPR , HSP
T9465	ZZW-115 hydrochloride		Apoptosis , Others
	ZZW-115 hydrochloride inhibits the activity of NUPR1.		Apoptosis , Others
T9831	MKC-1	Ro-31-7453	Apoptosis , Akt , Microtubule Associated , mTOR
	MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the format...		Apoptosis , Akt , Microtubule Associated , mTOR
T2667	PIK-75		Apoptosis , DNA-PK , PI3K
	PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).		Apoptosis , DNA-PK , PI3K
T2613	Almorexant	ACT 078573	OX Receptor
	Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.		OX Receptor
T6916	OICR-9429	OICR 9429	Histone Methyltransferase , JAK
	OICR-9429 is a potent antagonist of the interaction that WDR5 effect with peptide regions of MLL and Histone 3. It reduces the viability of acute myeloid leukemia cells in vitro.		Histone Methyltransferase , JAK
T15017	CU-T12-9		TLR
	CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat...		TLR
T7539	O6-Benzylguanine		Apoptosis , DNA Alkylation , DNA/RNA Synthesis
	O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.		Apoptosis , DNA Alkylation , DNA/RNA Synthesis
T2148	Carbidopa monohydrate	Carbidopa Hydrate,S(-)-Carbidopa	Decarboxylase , Aryl Hydrocarbon Receptor
	Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.		Decarboxylase , Aryl Hydrocarbon Receptor
T9240	Sulfopin	Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-	Others
	Sulfopin is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17nM. Sulfopin blocks Myc-driven tumors in vivo.		Others